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4-Sulfocalix[6]arene hydrate

Chemical Structure : 4-Sulfocalix[6]arene hydrate

CAS No.: 102088-39-1

4-Sulfocalix[6]arene hydrate

Catalog No.: PC-49331Not For Human Use, Lab Use Only.

4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.

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Biological Activity

4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
4-Sulfonic calix[6]arene shows IC50 of 2.2 and 3.0 uM for poly dA:dT-induced cell death and IL-1β release respectively.
4-Sulfonic calix[6]arene is effective at blocking dsDNA-induced inflammasome activation in LPS-primed human blood monocyte-derived macrophages (hMDMs).
4-Sulfonic calix[6]arene caused a dose-dependent inhibition in poly dA:dT-induced IFN-β release from murine BMDMs with IC50 of 10.72 uM, also reduced the phosphorylation of TBK1 and IRF-3 to a similar extent as the STING inhibitor H151.

Physicochemical Properties

M.Wt 1117.1
Formula C42H36O24S6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Sulfocalix[6]arene

References

1. Jack P Green, et al. iScience. 2023 Apr 27;26(5):106758.

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